The Team

Jose Luis Trejo Pérez

Responsible of Section of Laboratory of Adult Neurogenesis at Cajal Institute (CSIC, Madrid).

Our objective

The work of the group focuses on both basic and therapeutic aspects of the formation of new neurons in the adult brain. Special attention is given to the effect of the physical exercise and an enriched environment or stress. With this goal, we evaluate hippocampus-dependent learning and memory, anxiety-like and depressive-like behaviours, as well as its impairments during some neurodegenerative diseases.

In our work "Involvement of specific adult hippocampal neurogenic subpopulations on behavior acquisition and persistence abilities", the group analyzed the relationship between the task acquisition scores and the persistence in the acquired behavior and whether a correlation exists between the composition and number of the different subpopulations of immature neurons in the adult murine hippocampus and those acquisition/persistence behavioral parameters.

We worked full day during more than 8 weeks analysing every correlation between the variables captured. To do that, We used classical statistical packages but very few relevant relationships were identified mainly due to the extremely high amount of manual work required.

Which Was The Contribution Of ?

took less than 2 hours to find out not only all the correlations that the group had identified during our 8-weeks intensive work but also several key correlations that, with a further confirmatory phase, completed the original hypothesis.